2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-143982S
    Mianserin EP impurity E-d4 hydrochloride
    Mianserin EP impurity E-d4 (hydrochloride) is the deuterium labeled Mianserin EP impurity E hydrochloride[1].
    Mianserin EP impurity E-d<sub>4</sub> hydrochloride
  • HY-133677S
    Mono(2-ethyl-5-hydroxyhexyl) phthalate-d4
    Mono(2-ethyl-5-hydroxyhexyl) phthalate-d4 (MEHHP-d4) is a deuterium labeled Mono(2-ethyl-5-hydroxyhexyl) phthalate (HY-133677). Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) is an oxidative metabolite of Di(2-ethylhexyl) phthalate (DEHP). Mono(2-ethyl-5-hydroxyhexyl) phthalate may protective sperm DNA damage. Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking.
    Mono(2-ethyl-5-hydroxyhexyl) phthalate-d<sub>4</sub>
  • HY-15550S1
    4'-Hydroxy diclofenac-13C6
    4'-Hydroxy diclofenac-13C6 is the 13C labeled 4'-Hydroxy diclofenac[1]. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[2][3].
    4'-Hydroxy diclofenac-<sup>13</sup>C<sub>6</sub>
  • HY-116687
    7-Aminoflunitrazepam
    7-Aminoflunitrazepam is the main urinary metabolite of Flunitrazepam.
    7-Aminoflunitrazepam
  • HY-157690A
    19(R),20(S)-EDP
    19(R),20(S)-EDP (compound 19(S),20(R)-2a) is an oxylipin and a metabolite of docosahexaenoic acid (HY-B2167).
    19(R),20(S)-EDP
  • HY-161125
    (+)-JQ1-OH
    (+)-JQ1-OH is the major metabolite of (+)-JQ1(HY-13030). (+)-JQ-1 (JQ1) is a potent, specific, and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1/2)). (+)-JQ-1 also activates autophagy.
    (+)-JQ1-OH
  • HY-12753S1
    Debutyldronedarone-d6 hydrochloride
    Debutyldronedarone-d6 (hydrochloride) is deuterium labeled Debutyldronedarone. Debutyldronedarone is a major circulating active metabolite of dronedarone (HY-A0016) in humans. Debutyldronedarone exhibits a potency that is 1/10 to 1/3 of that of the parent agent[1][2].
    Debutyldronedarone-d<sub>6</sub> hydrochloride
  • HY-13318A
    Oseltamivir acid hydrochloride
    		≥98.0%
    Oseltamivir acid hydrochloride is an active metabolite of the antiviral agent Oseltamivir (HY-13317) ethylester. Oseltamivir acid hydrochloride belongs to baseline toxicants in toxicity ratio analysis.
    Oseltamivir acid hydrochloride
  • HY-135385
    Dihydro Dutasteride
    Dihydro Dutasteride is a metabolite of Dutasteride. Dutasteride is a potent inhibitor of both 5 alpha-reductase isozymes.
    Dihydro Dutasteride
  • HY-W778608R
    Quercetin 7-glucuronide (Standard)
    Dopamine (hydrochloride) (Standard) is the analytical standard of Dopamine (hydrochloride). This product is intended for research and analytical applications. Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2/KDR/Flk-1, which is critical for promoting angiogenesis.
    Quercetin 7-glucuronide (Standard)
  • HY-128532
    Formononetin 7-O-β-D-glucuronide
    Formononetin 7-O-β-D-glucuronide is a metabolite of Formononetin (HY-N0183) and can be absorbed and metabolized through the intestine.
    Formononetin 7-O-β-D-glucuronide
  • HY-B0602S1
    (S)-(+)-O-Desmethyl Venlafaxine-d6
    		99.77%
    (S)-(+)-O-Desmethyl Venlafaxine-d6 is the deuterium labeled (S)-(+)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine[1]. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class[2].
    (S)-(+)-O-Desmethyl Venlafaxine-d<sub>6</sub>
  • HY-100750R
    Norverapamil (hydrochloride) (Standard)
    Norverapamil (hydrochloride) (Standard)
  • HY-124414S
    4'-Hydroxytamoxifen-d6 (contains up to 10% E isomer)
    4'-Hydroxytamoxifen-d6 (contains up to 10% E isomer) is deuterium labeled 4'-Hydroxy Tamoxifen. 4'-Hydroxytamoxifen is a metabolite of Tamoxifen.
    4'-Hydroxytamoxifen-d<sub>6</sub> (contains up to 10% E isomer)
  • HY-131282
    Ivabradine impurity 2
    Ivabradine impurity 2 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker.
    Ivabradine impurity 2
  • HY-W008614R
    Lansoprazole sulfone (Standard)
    Lansoprazole sulfone (Standard) is the analytical standard of Lansoprazole sulfone. This product is intended for research and analytical applications. Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H+, K+-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H+, K+-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease.
    Lansoprazole sulfone (Standard)
  • HY-136577
    RP101442
    RP101442, an active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 2.6 nM and 171 nM for S1PR1 and S1PR5, respectively.
    RP101442
  • HY-W040705R
    2-(Methylamino)benzoic acid (Standard)
    2-(Methylamino)benzoic acid (Standard)
  • HY-130569S2
    7-Hydroxymethotrexate-d3 ammonium
    7-Hydroxymethotrexate-d3 (ammonium) is the deuterium labeled 7-Hydroxymethotrexate ammonium. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].
    7-Hydroxymethotrexate-d<sub>3</sub> ammonium
  • HY-G0004R
    Acetaminophen metabolite 3-hydroxy-acetaminophen (Standard)
    Acetaminophen metabolite 3-hydroxy-acetaminophen (Standard)
Cat. No. Product Name / Synonyms Application Reactivity